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The weekend brings the initial Wear-Tyne derby after 2024, but which side will celebrate – Sunderland or Newcastle?
"For most of last season, no one would have predicted Sunderland earning promotion and holding their own with Eddie Howe's Newcastle, never mind being above them in the table," remarked pundit Chris Sutton.
"It is very different now, and the way Sunderland play convinces me they've got a real chance."
The analyst is providing predictions for all 380 Premier League games this season, against artificial intelligence, the public and a assortment of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the eLions – the Football Association's official esports team – at the football simulation Uefa eEuro 2025 finals tournament, which takes place at Twickenham Stadium on Saturday.
You can watch Uefa's video platform, IG Live and TikTok channels, as well as EA Sports FC Twitch and its YouTube counterpart and England's Twitch.
Do you agree with their predictions? Feel free to submit your own predictions below.
The fan-favourite scoreline picked for each game is featured in the scoreboards at the foot of this page.
Predicting the right outcome (choosing a win, draw or defeat) is worth 10 points. The exact score earns 40 points.
Ray, who competes for Gen City and the Premier League champions as well as England, is entering the fray at the eEuros finals after successfully navigating the qualification rounds.
A group of eight will play for their countries at the finals in a straight knockout, playing for a $100,000 prize pool and a coveted spot in the world finals play-offs, with Denmark's Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray remarked. "I have a really good coach with me and training has been going well.
"Representing your country is always an honour to play for your country. Naturally when you are younger, you fantasise about doing it as an actual footballer, but when you go into this job and there is an opportunity to represent England, donning the national jersey is something special.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him over the course of the season just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"For me he is the number one in the world so defeating him in a tournament like this just provides a crazy boost of confidence."
Premier League Forecasts
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were impressive against the Gunners at the end of November, when they earned a stalemate after being reduced to 10 men, and I was thinking this is it, they could possibly be challengers for the crown.
Since then, however, they were outfought by Leeds, looked uninspired against Bournemouth and this week got defeated by Atalanta in the Champions League.
So head coach Enzo Maresca desperately requires a win here to return to winning ways, but it will be a challenge because the Merseyside club are such a threatening team.
Two of their stars are playing at the top of their game and they have got a bit of form at the moment.
Based on recent performances you would likely back Everton, while the most sensible prediction would probably be a draw, but I am not going to be sensible.
Chelsea haven't given me any good cause to back them recently, but I just have a gut instinct they will win this match because they are at home and they are in need of three points.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be fascinating to see what we get from the Reds.
I was delighted for Reds boss Arne Slot to get such a crucial result at Inter Milan on Tuesday following all the discussion with Mohamed Salah this week.
Slot should not have to put up with that distraction. I know Salah has been a great for the club but fundamentally Slot just wants to win games and there is nothing personal in his team selection.
They changed their formation against Inter and went with a midfield diamond formation and two up top.
All the talk is going to be talking about whether Salah is selected for this game, but the only way he is going to be reintegrated is if he apologises.
Slot's attention will be on winning this game, but it is a difficult fixture.
You could argue it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are vulnerable at the back too.
The Merseysiders need to get back to a consistent run of form, but I am not sure how much their exertions at the San Siro will have affected their stamina.
I put a couple of Brighton players in my FPL team, so they will likely do poorly - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Wearside club have had the week off while Newcastle had to battle intensely against Bayer Leverkusen on Wednesday, only to be pegged back late on.
Aside from their brilliant performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, particularly straight after they've played in the Champions League.
The pattern suggests that trend to continue on Sunday, and their tiredness is likely to be a factor in how this game goes because of their rivals' energetic style.
We saw how unwavering Regis le Bris's side are. They dominated the Gunners, and it was incredible to watch.
Commentators talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been brilliant, but Noah Sadiki, who plays alongside him, has also been one of the best acquisitions and warrants praise too.
All signs point to this being the best game|most exciting fixture